Most not too long ago, it's been discovered that conolidine and the above mentioned derivatives act within the atypical chemokine receptor 3 (ACKR3. Expressed in similar parts as classical opioid receptors, it binds to some big range of endogenous opioids. Not like most opioid receptors, this receptor acts for a scavenger and would not activate a n

Conolodine is prescription only and, I am pretty specific can only be prescribed by ache expert or presumably GPs with the pain/opiates certification.Szpakowska et al. also researched conolidone and its action over the ACKR3 receptor, which will help to elucidate its previously unidentified mechanism of action in the two acute and Serious pain Hand